If you had it in storage without anything connected then I'd take a known working mic or line source and go through the 16 mic/line inputs to check that they work, that gain pots aren't dirty, and that the mic/line/pad switch isn't dirty or faulty for each channel (be it bad caps or pot/switch). If you have had it installed, do the same going through your patch panel, or pre-wired configuration instead.
For outputs, I would do as Mixerizer suggested with the internal OSC, and feed every output the same signal and verify it with a known working speaker/external mixer/ and/or scope/multimeter to verify that levels are consistent and clean.
For digital I/O, you can do loopback tests to confirm clocking...however, be careful to not have anything folding back into itself or through mains to avoid feedback loops. If you happen to have TDIF dubbing cables, you can do that going between the different TDIF ports...you can also create a makeshift version using 25-conductor flat ribbon cable and crimp 25-pin d-sub connectors flipping one end.
You can also run through the diagnostic menu/tests to confirm the internal hardware is good. If it's been a hot minute since it's been powered, you might consider a fresh internal battery (CR2032) as a preventative measure.