OK, then do this with your DM off:
1) Plug your Genelecs directly into your 1/4" CR outputs from the DM
2) Find your CR knob and turn it all the way down.
3) Plug your main outputs from your Focusrite into a pair of Line In jacks using any two channels you want. Just for the hell of it, lets use channels 15 and 16.
4) look just above the gain knob on channels 15 and 16, you will see a slide switch that says "0...-20...line" Slide that over to "line". Turn your gain knobs all the down to zero.
5) turn on your DM and make sure your Genelecs are on and set to a nominal and matching volume level.
Now you have the physical connections done...
But first, a few simple setup things, just to make sure you have stuff setup properly...
1) Above faders 15 and 16 you will see three buttons, one of which is labeled SEL. That will Select that channel so that you can do stuff with it (lights up Green). Press SEL on channel 15.
2) With Channel 15 Selected, look up to the left of your display screen next to the dark gray area of buttons. You will see a button labeled STEREO. Press that so that it lights up. You have just sent CH15 to the Stereo Buss.
3) Do exactly the same thing with Ch16.
4) Now, to the RIGHT of the main output LED meter lights, you will see another button labeled STEREO. Press that so it lights up as well.
5) IF you want to use the Focusrite as a stereo source (like a stereo soundtrack from the movie) then you will need to "link" channels 15 and 16. If you want to use each channel individually (like if you want to record a mic in one channel and a guitar in the other) you would not do this. To "link" the channels together, hit SEL on both channels at the same time. Now, in your display you will get a message asking if you want to link the channels. Hit ENTER next to the jog wheel to link them. Now your PAN works as a stereo balance knob, instead of an individual channel mono pan knob.
Ok, on to the routing stuff.....
1) hit ALT/ROUTING/INPUT tab (bottom left). Use the left button below the display to select the input tab. Hopefully you show M/L 1 to 16 already entered as input assignments to your DM input channels 1-16 on layer 1. If you do, then move on. if not, let me know.
2) hit ALT/MONITOR/MONITOR tab. Use the arrow keys to select your Studio Setup output. Use the jog wheel to select STEREO and select the radio button. hit enter.
Now, to play something out of your Focusrite. turn your Focusrite output knob up about halfway. Now put your ch15 and 16 faders, as well as your STEREO buss fader, up to unity and turn your gain knobs for 15 and 16 up a bit, making sure they match. Now turn up your CR output knob. You should have sound.