Regarding what was said about only using ADAT, or s/pdif...
From what I've read, VST System Link (VSL) is supposed to be able to work with any digital audio type, although the different types can't be combined together. I've only used coaxial s/pdif myself with VSL, running audio, VSL data... and have test ran midi through the same cable with great results (I record all midi tracks directly into a dedicated VSTi PC these days).
Just a side note on my own discovery & experience with using VST System Link...
VSL doesn't absolutely have to be in what Steinberg calls a 'ring network'. In the scenario of 3 or more computers in a VSL network, one computer can send it's VSL data from a digital output, into a distribution amp having the same type of digital connections. From here, the VSL signal can be sent out of all of the amplifiers outputs simultaneously to any number of computers as you have on your distribution amp has (a star network). The advantage with a distribution amp, is that when you have multiple computers, this will eliminate the accumulative latency issue that each computer adds in a typical 'ring' network.
If the distribution amp is in the form of a matrix switcher, you have many switching options that can really expand your capabilities. Any one of several computers can be chosen as your master at any given time, and any other computers can be chosen as your acting slaves at any given time, all by the pressing of a few buttons, without physically rerouting anything.
While the traditional 'ring' network may have some advantage with multiple users, in that any one user can press play/stop etc and make all others follow, in a one man set-up I think the 'ring' network advantages start to dwindle compared to using a matrix switcher (star network).
With a 'ring' network, say with 3 or more computers, all connecting computers in the VSL network MUST be turned on and synced up/on-line, otherwise the signals & VSL data won't be passed on, from say computer 1 to computer 3... if computer 2 is not turned on.
With a matrix switcher of say having 8 ins/8outs, and even if you had 8 computers, you can have as little as only 2 computers turned on, out of 8 in your network....anywhere in the computer chain of computers 1 through 8, and you can make them communicate via VSL.
Of course, those with only 2 computers in your VSL network, the above doesn't really apply, or offer much. Also, I've read that with VSL it's been recommended using the same interfaces on each computer.. however I can use my 2 Tascams, FW-1082 or FW-1884 in my VSL network along side my Aardvark Q10's. And very oddly enough, recently I read somewhere that Steinberg had recommended using the 'same version series' (as in like using Cubase 8 pro, with Cubase Artist 8 or Cubase Elements 8 etc) but I know this to be false, as Cubase 8 Pro works with any Cubase version, as far back as Cubase VST 5/32. VST 5/32 was the 1st version to have VSL, but can only work in a slave role with it's last update. Any version after that, can work as a master or slave.